   The '''spleen''' (from Greek σπλήν - ''splēn''[ σπλήν], Henry George Liddell, Robert Scott, ''A Greek-English Lexicon'', on Perseus Digital Library) is an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system.[ Spleen], Internet Encyclopedia of Science In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve of blood in case of hemorrhagic shock while also recycling iron. As a part of the mononuclear phagocyte system, it metabolizes hemoglobin removed from senescent erythrocytes. The globin portion of hemoglobin is degraded to its constitutive amino acids, and the heme portion is metabolized to bilirubin, which is subsequently shuttled to the liver for removal.Mebius RE, Kraal G. (2005). Structure and function of the spleen. Nat Rev Immunol. 5(8):606-16. PMID 16056254 It synthesizes antibodies in its white pulp and removes antibody-coated bacteria along with antibody-coated blood cells by way of blood and lymph node circulation. The spleen is purple and gray. Recently, it has been found to contain in its reserve half of the body's monocytes within the red pulp. These monocytes, upon moving to injured tissue (such as the heart), turn into dendritic cells and macrophages while promoting tissue healing.Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo J-L, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. (2009). Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites. Science, 325: 612-616. Jia T, Pamer EG. (2009). Dispensable But Not Irrelevant. Science, 325:549-550. [ Finally, the Spleen Gets Some Respect] By NATALIE ANGIER, New York Times, August 3, 2009 It is one of the centers of activity of the reticuloendothelial system and can be considered analogous to a large lymph node, as its absence leads to a predisposition toward certain infections.  ==Anatomy==   The spleen, in healthy adult humans, is approximately  in length. It usually weighs between [ eMedicine &gt; Splenomegaly] Author: David J Draper. Coauthor(s): Ronald A Sacher, Emmanuel N Dessypris, Lewis J Kaplan. Updated: Oct 4, 2009 and  and lies beneath the 9th to the 12th thoracic ribs.  Like the thymus, the spleen possesses only efferent lymphatic vessels.  The spleen is part of the lymphatic system.  The germinal centers are supplied by arterioles called ''penicilliary radicles''.  The spleen is unique in respect to its development within the gut. While most of the gut viscera are endodermally derived (with the exception of the neural-crest derived suprarenal gland), the spleen is derived from mesenchymal tissue. Specifically, the spleen forms within, and from, the dorsal mesentery.  However, it still shares the same blood supply — the celiac trunk — as the foregut organs.  ==Function==  of splenic tissue showing the red pulp (red), white pulp (blue) and a thickened inflamed capusule (mostly pink - top of image). H&amp;E stain.]] {| class=&quot;wikitable&quot; |- | '''Area''' || '''Function ''' || '''Composition'''  |-  | red pulp || Mechanical filtration of red blood cells. In mice: Reserve of monocytes|| * &quot;sinuses&quot; (or &quot;sinusoids&quot;) which are filled with blood * &quot;splenic cords&quot; of reticular fibers * &quot;marginal zone&quot; bordering on white pulp  |-  | white pulp || Active immune response through humoral and cell-mediated pathways. || Composed of nodules, called Malpighian corpuscles. These are composed of: * &quot;lymphoid follicles&quot; (or &quot;follicles&quot;), rich in B-lymphocytes * &quot;periarteriolar lymphoid sheaths&quot; (PALS), rich in T-lymphocytes |}  Other functions of the spleen are less prominent, especially in the healthy adult: * Production of opsonins, properdin, and tuftsin. * Creation of red blood cells. While the bone marrow is the primary site of hematopoiesis in the adult, the spleen has important hematopoietic functions up until the fifth month of gestation. After birth, erythropoietic functions cease, except in some hematologic disorders.  As a major lymphoid organ and a central player in the reticuloendothelial system, the spleen retains the ability to produce lymphocytes and, as such, remains an hematopoietic organ. * Storage of red blood cells and other formed elements.  In horses roughly 30% of the red blood cells are stored there. The red blood cells can be released when needed. In humans, up to a cup (236.5ml) of red blood cells can be held in the spleen and released in cases of hypovolemia.  It can also store platelets in case of an emergency. *  In mice, the spleen stores half the body's monocytes so that upon injury they can migrate to the injured tissue and transform into dendritic cells and macrophages and so assist wound healing.  ==Effect of removal==  Surgical removal causes: * modest increases in circulating white blood cells and platelets, *diminished responsiveness to some vaccines, * increased susceptibility to infection by bacteria and protozoa; in particular, there is an increased risk of sepsis from polysaccharide encapsulated bacteria.  A 28-year follow-up of 740 veterans of World War II who had their spleen removed on the battlefield found that those who had been splenectomised showed a significant excess of mortality from pneumonia (6 rather than the expected 1.3) and a significant excess of mortality from ischaemic heart disease (4.1 rather than the expected 3) but not from other conditions.Robinette CD, Fraumeni JF Jr. (1977). Splenectomy and subsequent mortality in veterans of the 1939-45 war. Lancet. Jul 16;2(8029):127-9. PMID 69206   ==Disorders==  Disorders include splenomegaly, where the spleen is enlarged for various reasons, and asplenia, where the spleen is not present or functions abnormally.  ==Etymology and cultural views== The word '''spleen''' comes from the Greek σπλήν, and is the idiomatic equivalent of the heart in English, i.e. to be good-spleened (εὔσπλαγχνος) means to be good-hearted or compassionate.Robertson's Word Pictures of the New Testament, commentary on 1 Peter 3:8  In English the word ''spleen'' was customary during the period of the 18th century. Authors like Richard Blackmore or George Cheyne employed it to characterize the hypocondriacal and hysterical affections.Cheyne, George: ''The English Malady; or, A Treatise of Nervous Diseases of All Kinds, as Spleen, Vapours, Lowness of Spirits, Hypochondriacal and Hysterical Distempers with the Author's own Case at large'', Dublin, 1733. Facsimile ed., ed. Eric T. Carlson, M.D., 1976, Scholars' Facsimiles &amp; Reprints, ISBN 9780820112817;Blackmore, Richard: ''Treatise of the spleen and vapors''. London, 1725  In French, &quot;splénétique&quot; refers to a state of pensive sadness or melancholy. It has been popularized by the poet Charles Baudelaire (1821–1867) but was already used before in particular to the Romantic literature (18th century). The word for the organ is &quot;la rate.&quot;  The connection between ''spleen'' (the organ) and ''melancholy'' (the temperament) comes from the humoral medicine of the ancient Greeks. One of the humours (body fluid) was the black bile, secreted by the spleen organ and associated with melancholy. In contrast, the Talmud (tractate Berachoth 61b) refers to the spleen as the organ of laughter while possibly suggesting a link with the humoral view of the organ. In the eighteenth- and nineteenth-century England, women in bad humour were said to be afflicted by the spleen, or the vapours of the spleen. In modern English, &quot;to vent one's spleen&quot; means to vent one's anger, e.g. by shouting, and can be applied to both males and females. Similarly, the English term &quot;splenetic&quot; is used to describe a person in a foul mood.  In Chinese, the spleen '脾 (pí)' counts as the seat of one's temperament and is thought to influence the individual's willpower. Analogous to &quot;venting one's spleen&quot;, &quot;發脾氣&quot; is used as an expression for getting angry, although in the view of Traditional Chinese Medicine, the view of &quot;脾&quot; does not correspond to the anatomical &quot;spleen&quot;. &quot;脾&quot; is a conceptual functional group that mainly has regards to digestion which, in some scholars' opinions, corresponds to the function of the pancreas.  ==Variation among vertebrates== In cartilagenous and ray-finned fish it consists primarily of red pulp and is normally a somewhat elongated organ as it actually lies inside the serosal lining of the intestine. In many amphibians, especially frogs, it takes on the more rounded form and there is often a greater quantity of white pulp.  In reptiles, birds, and mammals, white pulp is always relatively plentiful, and in the latter two groups, the spleen is typically rounded, although it adjusts its shape somewhat to the arrangement of the surrounding organs.  In the great majority of vertebrates, the spleen continues to produce red blood cells throughout life; it is only in mammals that this function is lost in the adult. Many mammals possess tiny spleen-like structures known as '''haemal nodes''' throughout the body, which presumably have the same function as the spleen proper. The spleens of aquatic mammals are in some ways dissimilar to those of fully land dwelling mammals. In general the spleens of aquatic mammals are bluish in colour.  In cetaceans and manatees it tends to be quite small, but in deep diving pinnipeds it can be quite massive, owing to its function of storing red blood cells.  The only vertebrates lacking a spleen are the lampreys and hagfishes. Even in these animals, there is a diffuse layer of haematopoeitic tissue within the gut wall, which has a similar structure to red pulp, and is presumably homologous with the spleen of higher vertebrates.  